Pub. Date : 2008 Aug 15
PMID : 18446786
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | We have investigated the mechanism by which resveratrol, a stilbene that is pro-apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC-22B cells by a mechanism involving cellular COX-2. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Resveratrol also caused p53 binding to the p21 promoter and increased abundance of COX-2 protein in UMSCC-22B cell nuclei. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Resveratrol-induced nuclear COX-2 accumulation was dependent upon ERK1/2 activation, but not p53 activation. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | In UMSCC-22B cells, resveratrol-induced apoptosis and induction of nuclear COX-2 accumulation share dependence on the ERK1/2 signal transduction pathway. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Resveratrol-inducible nuclear accumulation of COX-2 is essential for p53 activation and p53-dependent apoptosis in these cancer cells. | Resveratrol | prostaglandin-endoperoxide synthase 2 | Homo sapiens |