Title : Effect of intermittent oral 1,25(OH)2D3 therapy on bone Gla protein in dialysis patients.

Pub. Date : 1991 Oct

PMID : 1843267






6 Functional Relationships(s)
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1 The administration of active vitamin D3 gradually increased the serum BGP to more than 3 times the original level by the 8th week. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
2 At the 12th week after starting the active vitamin D3 therapy, mean BGP was about twice the original level, which was about half the maximum level at the 8th week. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
3 These data suggest that BGP was increased through direct stimulation of osteoblasts by the active vitamin D3, and the increase was not due to deterioration of secondary hyperparathyroidism. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
4 The reduction of the increase in the BGP level at the 12th week with insignificant biochemical changes suggest that activation of osteoblasts by vitamin D3 may be transient. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
5 In conclusion, intermittent active vitamin D3 increases serum BGP, without deterioration of major biochemical changes even in patients with moderate to severe secondary hyperparathyroidism, although the increase may be transient. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens
6 These facts suggest that the serum BGP of hemodialysis patients is controlled at least in part by active vitamin D3. Cholecalciferol bone gamma-carboxyglutamate protein Homo sapiens