Title : Dose-dependent and sequence-dependent cytotoxicity of erlotinib and docetaxel in head and neck squamous cell carcinoma.

Pub. Date : 2008 Jun

PMID : 18418213






3 Functional Relationships(s)
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1 The low and high doses of docetaxel had opposite effects on EGFR expression: a decrease and an increase, respectively. Docetaxel epidermal growth factor receptor Homo sapiens
2 The dose of docetaxel affects sequence-dependent cytotoxicity when docetaxel is combined with an EGFR inhibitor. Docetaxel epidermal growth factor receptor Homo sapiens
3 The mechanism for this difference is a combination of the dose-dependent effects of docetaxel on the mode of cell death and on EGFR expression. Docetaxel epidermal growth factor receptor Homo sapiens