Pub. Date : 2008 Oct
PMID : 18412143
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As2O3-induced apoptotic cell death in HeLa cells was associated with activation and mitochondrial translocation of Bax, a marked phosphorylation of Bcl-2, reduction of Bcl-2 and Bax interaction, dissipation of mitochondrial membrane potential. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | As2O3-induced apoptotic cell death in HeLa cells was associated with activation and mitochondrial translocation of Bax, a marked phosphorylation of Bcl-2, reduction of Bcl-2 and Bax interaction, dissipation of mitochondrial membrane potential. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | Using small interfering RNA, reduced Bax expression effectively attenuated As2O3-induced mitochondrial membrane potential loss and apoptotic cell death. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Moreover, the phosphorylation of Bcl-2 induced by As2O3 diminished its ability to bind to Bax. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 5 | In addition, N-acetyl-L-cystein (NAC), a thiol-containing anti-oxidant, completely blocked As2O3-induced p38 MAPK and JNK activations, mitochondria translocation of Bax, and phosphorylation of Bcl-2. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 6 | These results support a notion that ROS-mediated activations of p38 MAPK and JNK in response to As2O3 treatment signals activation of Bax and phosphorylation of Bcl-2, resulting in mitochondrial apoptotic cell death in human cervical cancer cells. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |