Pub. Date : 2008 May
PMID : 18408565
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | OBJECTIVE: This study was addressed to understand the underlying mechanism of the substrate-dependent effect of genetic variation in SLCO1B1, which encodes OATP1B1 (organic anion transporting polypeptide) transporter, on the disposition of two OATP1B1 substrates, pravastatin and pitavastatin, in relation to their transport activities. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | OBJECTIVE: This study was addressed to understand the underlying mechanism of the substrate-dependent effect of genetic variation in SLCO1B1, which encodes OATP1B1 (organic anion transporting polypeptide) transporter, on the disposition of two OATP1B1 substrates, pravastatin and pitavastatin, in relation to their transport activities. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | OBJECTIVE: This study was addressed to understand the underlying mechanism of the substrate-dependent effect of genetic variation in SLCO1B1, which encodes OATP1B1 (organic anion transporting polypeptide) transporter, on the disposition of two OATP1B1 substrates, pravastatin and pitavastatin, in relation to their transport activities. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 6 | RESULTS: The uptake of pravastatin and pitavastatin in SLCO1B1*15 overexpressing oocytes was decreased compared with that in SLCO1B1*15, but no change occurred with fluvastatin. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 7 | The greater decrease in the transport activity for pitavastatin in SLCO1B1*15 variant compared with SLCO1B1*1a was, however, associated with the greater effect on the pharmacokinetics of pitavastatin compared with pravastatin in relation to the SLCO1B1 genetic polymorphism. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 8 | The greater decrease in the transport activity for pitavastatin in SLCO1B1*15 variant compared with SLCO1B1*1a was, however, associated with the greater effect on the pharmacokinetics of pitavastatin compared with pravastatin in relation to the SLCO1B1 genetic polymorphism. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 9 | The greater decrease in the transport activity for pitavastatin in SLCO1B1*15 variant compared with SLCO1B1*1a was, however, associated with the greater effect on the pharmacokinetics of pitavastatin compared with pravastatin in relation to the SLCO1B1 genetic polymorphism. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 10 | CONCLUSION: This study suggests that substrate dependency in the consequences of the SLCO1B1*15 variant could modulate the effect of SLCO1B1 polymorphism on the disposition of pitavastatin and pravastatin. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 11 | CONCLUSION: This study suggests that substrate dependency in the consequences of the SLCO1B1*15 variant could modulate the effect of SLCO1B1 polymorphism on the disposition of pitavastatin and pravastatin. | Pravastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |