Title : Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

Pub. Date : 2008 Apr 16

PMID : 18398104






1 Functional Relationships(s)
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1 Using the antioxidant ascorbic acid and siRNA-mediated knockdown of JNK, we showed that 4-HPR decreased Mcl-1 via ROS generation (that phosphorylates JNK) in ABT-737-resistant cell lines. Ascorbic Acid haptoglobin-related protein Homo sapiens