Title : Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.

Pub. Date : 2008 Apr 8

PMID : 18388203






1 Functional Relationships(s)
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1 The chemical insights gleaned from this work pave the foundation toward defining the molecular rules for the ARO/CYC cyclization specificity, whose rational control will be important for future endeavors in the engineered biosynthesis of novel anticancer and antibiotic aromatic polyketides. Polyketides cytochrome P450 family 19 subfamily A member 1 Homo sapiens