Pub. Date : 2008 Apr
PMID : 18383384
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. | pristane | toll-like receptor 7 | Mus musculus |
| 2 | The purpose of this study was to investigate the role of TLR-7 in anti-snRNP antibody production and renal disease in SLE induced by an exogenous factor in the absence of genetic predisposition, using the pristane-induced murine lupus model. | pristane | toll-like receptor 7 | Mus musculus |
| 3 | RESULTS: We found that anti-snRNP antibody production induced by pristane treatment was entirely dependent on the expression of TLR-7, whereas anti-double-stranded DNA antibody production was not affected by a lack of TLR-7. | pristane | toll-like receptor 7 | Mus musculus |
| 4 | CONCLUSION: TLR-7 is specifically required for the production of RNA-reactive autoantibodies and the development of glomerulonephritis in pristane-induced murine lupus, a model of environmentally triggered SLE in the absence of genetic susceptibility to autoimmunity. | pristane | toll-like receptor 7 | Mus musculus |