Title : Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2.

Pub. Date : 2008 Jun

PMID : 18383341






1 Functional Relationships(s)
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1 The LPS-induced increase of mPGES-1 was inhibited by different signaling pathway inhibitors, such as SP600125, LY294002, GF109203X, and SC-514, suggesting the involvement of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI-3K)/Akt, protein kinase C (PKC) pathways, and the nuclear factor (NF)-kappaB, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 8 Rattus norvegicus