Title : Citrinin induces apoptosis in mouse embryonic stem cells.

Pub. Date : 2008 Mar

PMID : 18380009






1 Functional Relationships(s)
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1 Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation. Citrinin cyclin-dependent kinase inhibitor 1A (P21) Mus musculus