PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18380009-5 2008 Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation. Citrinin 69-72 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 356-359