Pub. Date : 2008 Apr
PMID : 18379048
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous molecular dynamics studies from our laboratory indicated that the amino acids Asp106 in the third transmembrane domain (TMD), Gln167 in TMD IV of alpha 1a-AR were directly involved in prazosin, tamsulosin and KMD-3213 binding. | Prazosin | adrenoceptor alpha 1A | Homo sapiens |
| 2 | On the other hand, the Gln167Phe mutant alpha 1a-AR showed reduced binding affinity for [3H]prazosin. | Prazosin | adrenoceptor alpha 1A | Homo sapiens |
| 3 | The results provide direct evidence that these amino acid residues are responsible for the interactions between alpha 1a-AR and radioligand [3H]prazosin as well as tamsulosin and KMD-3213. | Prazosin | adrenoceptor alpha 1A | Homo sapiens |