Pub. Date : 2008 May 15
PMID : 18377872
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | To test this hypothesis, we selectively inhibited MAPK during treatment with quercetin. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Our data demonstrated that inhibitor of ERK (PD98059), but not p38 MAPK (SB203580) or JNK (SP600125), significantly maintained the intracellular level of survivin during treatment with quercetin. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Quercetin-induced activation of the ERK-MSK1 signal transduction pathway may be responsible for deacetylation of histone H3. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Taken together, our findings suggest that quercetin enhances TRAIL induced apoptosis by inhibition of survivin expression, through ERK-MSK1-mediated deacetylation of H3. | Quercetin | mitogen-activated protein kinase 1 | Homo sapiens |