Pub. Date : 2008 Dec
PMID : 18373738
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1. | Sildenafil Citrate | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | Our study aimed to determine a novel role of sildenafil on cardioprotection through stimulating angiogenesis during ischaemia (I) reperfusion (R) at both capillary and arteriolar levels and to examine the role of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) in this mechanistic effect. | Sildenafil Citrate | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | Treatment with sildenafil demonstrated increased VEGF and Ang-1 mRNA after early reperfusion. | Sildenafil Citrate | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | Our study demonstrated for the first time a strong additional therapeutic potential of sildenafil by up-regulating VEGF and Ang-1 system, probably by stimulating a cascade of events leading to neovascularization and conferring myocardial protection in in vivo I/R rat model. | Sildenafil Citrate | vascular endothelial growth factor A | Rattus norvegicus |