Title : Efficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation.

Pub. Date : 2008 Jun 1

PMID : 18359283






1 Functional Relationships(s)
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1 Our results, and a structure model based on the crystal structures of the ferrous dioxygen complexes of P450(cam) and its T252A mutant, suggest that Asn252 can stabilize the ferric hydroperoxy intermediate, preventing premature release of H(2)O(2) and enabling addition of the second proton to the distal oxygen to generate the catalytic ferryl species. Hydrogen Peroxide calmodulin 3 Homo sapiens