Title : The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS.

Pub. Date : 2008 Apr 9

PMID : 18354494






1 Functional Relationships(s)
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1 Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surrounding membrane, (b) required for the fission of the macropinocytic cup and (c) phosphorylated on a specific serine that is a substrate for p21-activated kinase, with this phosphorylation being essential for the fission of the macropinocytic cup. Serine epidermal growth factor receptor Homo sapiens