Pub. Date : 2008 May
PMID : 18353872
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells: involvement of Syk tyrosine kinase. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 2 | Activation of nuclear factor-kappaB (NF-kappaB) occurs by dissociation from IkappaB after serine or tyrosine phosphorylation of IkappaBalpha, but the way of NF-kappaB activation by high glucose has not been defined. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 3 | In agreement with this, there was no increase in serine phosphorylation of IkappaBalpha, while tyrosine phosphorylation of IkappaBalpha was increased by high glucose. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 4 | Protein kinase C pseudosubstrate inhibited high glucose-induced ROS production, tyrosine phosphorylation of IkappaBalpha, and nuclear translocation of p65. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 5 | Our data suggest that ROS-mediated tyrosine phosphorylation of IkappaBalpha is the mechanism for high glucose-induced NF-kappaB activation, and Syk may play a role in tyrosine phosphorylation of IkappaBalpha. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |
| 6 | Our data suggest that ROS-mediated tyrosine phosphorylation of IkappaBalpha is the mechanism for high glucose-induced NF-kappaB activation, and Syk may play a role in tyrosine phosphorylation of IkappaBalpha. | Tyrosine | NFKB inhibitor alpha | Homo sapiens |