Title : Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.

Pub. Date : 2008 Mar 15

PMID : 18347191






1 Functional Relationships(s)
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1 We found that blocking ATM/ATR signaling with pharmacologic inhibitors, including the novel ATM inhibitors KU55933 and CGK733, induced senescent breast, lung, and colon carcinoma cells to undergo cell death. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one ATR serine/threonine kinase Homo sapiens