Title : An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.

Pub. Date : 2008 Jun

PMID : 18339713






2 Functional Relationships(s)
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1 Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels. Diethylstilbestrol estrogen receptor 2 (beta) Mus musculus
2 Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels. Diethylstilbestrol estrogen receptor 2 (beta) Mus musculus