Title : Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line.

Pub. Date : 2008 May 15

PMID : 18336853






1 Functional Relationships(s)
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1 In comparison, 10(-7) to 2 x 10(-5) M PNMPP with 1 mM 8-Br-cAMP for 48 h decreased concentrations of estradiol-17beta, increased progesterone levels, but did not affect testosterone and cortisol secretion due to the significant suppression of CYP17 and the non-significant but obvious suppression of CYP19. 8-Bromo Cyclic Adenosine Monophosphate cytochrome P450 family 17 subfamily A member 1 Homo sapiens