Pub. Date : 1991 Oct
PMID : 1833422
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Murine antisense oligonucleotides inhibited IL-1-stimulated PGE2 synthesis by murine fibroblasts in culture in a time (days) and concentration-dependent (3 microM-30 microM) fashion. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 2 | Similarly, antisense oligonucleotides to the human, but not the murine, IL-1 receptor inhibited IL-1-stimulated PGE2 synthesis by cultured human fibroblasts. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 3 | The attenuation of the cellular response to IL-1 caused by the antisense oligonucleotides correlated with a loss in cell surface receptors for IL-1, without any change in the number of bradykinin receptors on these cells. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 4 | The attenuation of the cellular response to IL-1 caused by the antisense oligonucleotides correlated with a loss in cell surface receptors for IL-1, without any change in the number of bradykinin receptors on these cells. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 5 | When antisense oligonucleotides were encapsulated in liposomes, they blocked completely the appearance of newly synthesized IL-1 receptors and IL-1-stimulated PGE2 synthesis. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 6 | When antisense oligonucleotides were encapsulated in liposomes, they blocked completely the appearance of newly synthesized IL-1 receptors and IL-1-stimulated PGE2 synthesis. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 7 | In mice, subcutaneous injection with an oligonucleotide antisense to the murine IL-1 receptor markedly inhibited the infiltration of neutrophils in response to subsequent injection of IL-1. | Oligonucleotides | interleukin 1 complex | Mus musculus |
| 8 | In mice, subcutaneous injection with an oligonucleotide antisense to the murine IL-1 receptor markedly inhibited the infiltration of neutrophils in response to subsequent injection of IL-1. | Oligonucleotides | interleukin 1 complex | Mus musculus |