PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1833422-2 1991 Murine antisense oligonucleotides inhibited IL-1-stimulated PGE2 synthesis by murine fibroblasts in culture in a time (days) and concentration-dependent (3 microM-30 microM) fashion. Oligonucleotides 17-33 interleukin 1 complex Mus musculus 44-48 1833422-5 1991 Similarly, antisense oligonucleotides to the human, but not the murine, IL-1 receptor inhibited IL-1-stimulated PGE2 synthesis by cultured human fibroblasts. Oligonucleotides 21-37 interleukin 1 complex Mus musculus 96-100 1833422-6 1991 The attenuation of the cellular response to IL-1 caused by the antisense oligonucleotides correlated with a loss in cell surface receptors for IL-1, without any change in the number of bradykinin receptors on these cells. Oligonucleotides 73-89 interleukin 1 complex Mus musculus 44-48 1833422-6 1991 The attenuation of the cellular response to IL-1 caused by the antisense oligonucleotides correlated with a loss in cell surface receptors for IL-1, without any change in the number of bradykinin receptors on these cells. Oligonucleotides 73-89 interleukin 1 complex Mus musculus 143-147 1833422-7 1991 When antisense oligonucleotides were encapsulated in liposomes, they blocked completely the appearance of newly synthesized IL-1 receptors and IL-1-stimulated PGE2 synthesis. Oligonucleotides 15-31 interleukin 1 complex Mus musculus 124-128 1833422-7 1991 When antisense oligonucleotides were encapsulated in liposomes, they blocked completely the appearance of newly synthesized IL-1 receptors and IL-1-stimulated PGE2 synthesis. Oligonucleotides 15-31 interleukin 1 complex Mus musculus 143-147 1833422-8 1991 In mice, subcutaneous injection with an oligonucleotide antisense to the murine IL-1 receptor markedly inhibited the infiltration of neutrophils in response to subsequent injection of IL-1. Oligonucleotides 40-55 interleukin 1 complex Mus musculus 80-84 1833422-8 1991 In mice, subcutaneous injection with an oligonucleotide antisense to the murine IL-1 receptor markedly inhibited the infiltration of neutrophils in response to subsequent injection of IL-1. Oligonucleotides 40-55 interleukin 1 complex Mus musculus 184-188