Title : Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.

Pub. Date : 2008 May

PMID : 18332107






1 Functional Relationships(s)
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1 Furthermore, both loading of heterochromatin-associated protein 1 (HP1alpha and HP1beta) to methylated H3K9 and binding of DNMT1 to these genes" promoter were significantly reduced in depsipeptide-treated cells. Depsipeptides chromobox 5 Homo sapiens