Pub. Date : 2008 Jun
PMID : 18331617
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MnSOD +/- and -/- MEFs demonstrated increased superoxide steady-state levels; these fibroblasts failed to exit from the proliferative cycle, and showed increasing cyclin D1 and cyclin B1 protein levels. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 2 | Overexpression of MnSOD in MnSOD +/- MEFs suppressed superoxide levels and G(2) accumulation, decreased cyclin B1 protein levels, and facilitated cells" transit into quiescence. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 3 | Overexpression of MnSOD in MnSOD +/- MEFs suppressed superoxide levels and G(2) accumulation, decreased cyclin B1 protein levels, and facilitated cells" transit into quiescence. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |
| 4 | These results support the hypothesis that MnSOD activity regulates a mitochondrial "ROS-switch" favoring a superoxide-signaling regulating proliferation and a hydrogen peroxide-signaling supporting quiescence. | Superoxides | superoxide dismutase 2, mitochondrial | Mus musculus |