Title : ARVC-related mutations in divergent region 3 alter functional properties of the cardiac ryanodine receptor.

Pub. Date : 2008 Jun

PMID : 18326664






2 Functional Relationships(s)
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1 Surprisingly, when both substitutions were introduced in the same RyR2 subunit (RyR2-G1885E/G1886S), the store-overload-induced calcium release activity was nearly completely abolished, although the Ca(2+) loading of the intracellular stores was markedly enhanced, and the channel still displayed substantial Ca(2+) release on stimulation by 5 mM caffeine. Calcium ryanodine receptor 2 Homo sapiens
2 Surprisingly, when both substitutions were introduced in the same RyR2 subunit (RyR2-G1885E/G1886S), the store-overload-induced calcium release activity was nearly completely abolished, although the Ca(2+) loading of the intracellular stores was markedly enhanced, and the channel still displayed substantial Ca(2+) release on stimulation by 5 mM caffeine. Calcium ryanodine receptor 2 Homo sapiens