Title : Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.

Pub. Date : 2008 May 2

PMID : 18321861






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human Grx1 showed similar reactivity as Trx1 with both mercurial compounds, with the loss of all free thiols and Grx dimerization in the presence of HgCl(2), but no inhibition of Grx activity was observed in lysates of HeLa cells exposed to mercury. Sulfhydryl Compounds glutaredoxin Homo sapiens
2 Human Grx1 showed similar reactivity as Trx1 with both mercurial compounds, with the loss of all free thiols and Grx dimerization in the presence of HgCl(2), but no inhibition of Grx activity was observed in lysates of HeLa cells exposed to mercury. Sulfhydryl Compounds glutaredoxin Homo sapiens