Pub. Date : 2009 Apr
PMID : 18317936
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels. | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 8 | These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos). | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 9 | These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos). | Oxysterols | C-X-C motif chemokine ligand 8 | Homo sapiens |