Title : Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.

Pub. Date : 2008 May 1

PMID : 18316628






1 Functional Relationships(s)
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1 We found that NPI-0052 inhibited proliferation and induced apoptosis in WM cells, and that the combination of NPI-0052 and bortezomib induced synergistic cytotoxicity in WM cells, leading to inhibition of nuclear translocation of p65NF-kappaB and synergistic induction of caspases-3, -8, and -9 and PARP cleavage. Bortezomib poly(ADP-ribose) polymerase 1 Homo sapiens