Title : Phospholipase C-gamma 1 directly associates with the p70 trk oncogene product through its src homology domains.

Pub. Date : 1991 Aug 15

PMID : 1831195






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Tyrosine phosphorylation of proteins was examined in NIH3T3 cells transformed by an oncogenic form of the trk protein. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
2 Proteins of 148, 140, 70, and 55 kDa were phosphorylated on tyrosine residues in trk-transformed cells but not control NIH3T3 cells. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
3 The 70-kDa protein may represent the trk oncogene protein itself which was shown to be tyrosine-phosphorylated in vivo using trk-specific antiserum. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
4 The 70-kDa protein may represent the trk oncogene protein itself which was shown to be tyrosine-phosphorylated in vivo using trk-specific antiserum. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
5 Phospholipase C-gamma 1 (PLC-gamma 1) was also found to be constitutively tyrosine-phosphorylated in trk-transformed cells and the trk protein co-immunoprecipitated with PLC-gamma. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
6 Phospholipase C-gamma 1 (PLC-gamma 1) was also found to be constitutively tyrosine-phosphorylated in trk-transformed cells and the trk protein co-immunoprecipitated with PLC-gamma. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
7 The GTPase-activating protein of ras (GAP) and the 62-kDa GAP-associated protein were tyrosine-phosphorylated in trk-transformed cells, and a lesser amount of trk co-immunoprecipitated with GAP relative to with PLC-gamma. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus