Title : Cytosolic half of transmembrane domain IV of the human bile acid transporter hASBT (SLC10A2) forms part of the substrate translocation pathway.

Pub. Date : 2008 Mar 25

PMID : 18311924






2 Functional Relationships(s)
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1 We report the involvement of transmembrane domain 4 (TM4) of hASBT in forming the putative translocation pathway, using cysteine-scanning mutagenesis in conjunction with solvent-accessibility studies using the membrane-impermeant, sulfhydryl-specific methanethiosulfonate reagents. Cysteine solute carrier family 10 member 2 Homo sapiens
2 We individually mutated each of the 21 amino acids in TM4 to cysteine on a fully functional, MTS-resistant C270A-hASBT template. Cysteine solute carrier family 10 member 2 Homo sapiens