Title : Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation.

Pub. Date : 2008 May

PMID : 18305408






1 Functional Relationships(s)
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1 Notably, siramesine triggers also a substantial Atg6- and Atg7-dependent accumulation of autophagosomes that is associated with a rapid and sustained inhibition of mammalian target of rapamycin complex 1 (mTORC1; an inhibitor of autophagy). Lu 28-179 autophagy related 7 Homo sapiens