Title : Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway.

Pub. Date : 2008 Feb

PMID : 18303439






1 Functional Relationships(s)
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1 In cell lines independent of the EGFR, expression of PTEN correlated with resistance to AKT inhibition, EGFR expression correlated to resistance to 17-AAG and L744832 and S6K1 as well as p-S6K1 expression correlated with sensitivity to rapamycin. tanespimycin epidermal growth factor receptor Homo sapiens