Title : 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pub. Date : 2008 Mar

PMID : 18300941






4 Functional Relationships(s)
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1 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 OBJECTIVES: To study the potential endogenous marker of CYP3A activity, 4beta-hydroxycholesterol, and its relation to sex and the CYP3A5 geno/haplotypes and compare with CYP3A4/5 catalyzed 3-hydroxylation of quinine in the three major races. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 The quinine/3-hydroxyquinine metabolic ratio was significantly different in all three populations with the highest CYP3A activity in Koreans and the lowest in Tanzanians. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 Both 4beta-hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio showed a higher CYP3A activity in women than in men. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens