Title : Dexamethasone interferes with trastuzumab-induced cell growth inhibition through restoration of AKT activity in BT-474 breast cancer cells.

Pub. Date : 2008 Mar

PMID : 18292946






2 Functional Relationships(s)
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1 Dex restored this trastuzumab-induced dephosphorylation of pRB and released trastuzumab-induced G1 arrest. Dexamethasone RB transcriptional corepressor 1 Homo sapiens
2 It was concluded that Dex interferes with trastuzumab-induced cell growth inhibition, at least partially, through the restoration of trastuzumab-induced AKT suppression and subsequent pRB dephosphorylation in BT-474 breast cancer cells. Dexamethasone RB transcriptional corepressor 1 Homo sapiens