Pub. Date : 2008 May
PMID : 18287519
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. | Nocodazole | ras homolog family member A | Homo sapiens |
| 2 | Furthermore, the nocodazole-induced activation of RhoA and Rho-associated kinase (ROCK) that mediates phosphorylation of myosin regulatory light chain (MLC) is impaired in GEF-H1-depleted cells. | Nocodazole | ras homolog family member A | Homo sapiens |
| 3 | Our studies reveal a critical role for a GEF-H1/RhoA/ROCK/MLC signaling pathway in mediating nocodazole-induced cell contractility. | Nocodazole | ras homolog family member A | Homo sapiens |