Title : Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells.

Pub. Date : 2008 Apr 25

PMID : 18281277






1 Functional Relationships(s)
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1 Exposure of cells to the saturated fatty acid palmitate led to enhanced diacylglycerol levels and the consequent activation of the protein kinase C/nuclear factor kappaB pathway, finally resulting in enhanced interleukin 6 secretion and down-regulation of the expression of genes involved in the control of the oxidative capacity of skeletal muscle (peroxisome proliferator-activated receptor (PPAR)gamma-coactivator 1alpha) and triglyceride synthesis (acyl-coenzyme A: diacylglycerol acyltransferase 2). saturated fatty acid palmitate interleukin 6 Homo sapiens