Title : PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease.

Pub. Date : 2008 Apr

PMID : 18278798






1 Functional Relationships(s)
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1 Motor behavior tests and tyrosine hydroxylase immunoreactivity revealed that the inhibitor of the PI3K/Akt pathway (LY294002) blocked the survival effects of both estrogen and IGF-1, while an inhibitor of the MAPK/ERK signaling (PD98059) was ineffective. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin-like growth factor 1 Rattus norvegicus