Pub. Date : 2008 Mar 5
PMID : 18262361
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice. | Morphine | pro-opiomelanocortin-alpha | Mus musculus |
| 2 | In the present study, we investigated whether a gene deletion for an endogenous mu-opioid peptide beta-endorphin could affect pain-like behavior and the suppression of the morphine-induced rewarding effect by the direct activation of PKC in the spinal cord. | Morphine | pro-opiomelanocortin-alpha | Mus musculus |
| 3 | This suppression of morphine reward was eliminated in mice that lacked beta-endorphin. | Morphine | pro-opiomelanocortin-alpha | Mus musculus |
| 4 | These results suggest that the activation of PKC in the spinal cord may play an essential role in the suppression of the morphine-induced rewarding effect in mice with neuropathic pain through the constant release of beta-endorphin. | Morphine | pro-opiomelanocortin-alpha | Mus musculus |