Pub. Date : 2007
PMID : 18261366
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Altered pharmacokinetics of daunorubicin in rats with CCl4-induced hepatic injury. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | PURPOSE: The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | PURPOSE: The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | PURPOSE: The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | RESULTS: The area under the plasma concentration-time curve (AUC) of daunorubicin was increased by 1.6 times, resulting in a 34% decrease in the systemic clearance (CL) in rats with CCl4-EHI. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 6 | CONCLUSIONS: CCl4-EHI appears to impair the hepatic metabolism of daunorubicin, thereby decreasing the CL and increasing the AUC of daunorubicin. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 7 | CONCLUSIONS: CCl4-EHI appears to impair the hepatic metabolism of daunorubicin, thereby decreasing the CL and increasing the AUC of daunorubicin. | Daunorubicin | C-C motif chemokine ligand 4 | Rattus norvegicus |