Title : Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells.

Pub. Date : 2008 Jul 1

PMID : 18247328






2 Functional Relationships(s)
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1 In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15). Tyrosine cyclin dependent kinase 1 Homo sapiens
2 Moreover, caffeine, a known ATM/ATR kinase inhibitor, relieved the phosphorylation of cdc2 (Tyr-15) by hydroxyurea, but not that by lithium. Tyrosine cyclin dependent kinase 1 Homo sapiens