Title : Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.

Pub. Date : 2008 Jun 1

PMID : 18245064






1 Functional Relationships(s)
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1 Remarkably, PARP inhibition in FCs resulted in significant sensitization to 7-ketocholesterol (7-KC) by increasing cellular-toxic-free cholesterol, potentially through a down-regulation of acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) expression. 7-ketocholesterol poly (ADP-ribose) polymerase family, member 1 Mus musculus