Title : 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.

Pub. Date : 2008 Mar 15

PMID : 18226909






1 Functional Relationships(s)
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1 A large series of piperazin-, piperidin- and tetrahydroisoquinolinamides of 4-(1,3-dialkyl-9-deazaxanthin-8-yl)phenoxyacetic acid were prepared through conventional or multiple parallel syntheses and evaluated for their binding affinity at the recombinant human adenosine receptors, chiefly at the hA(2B) and hA(2A) receptor subtypes. piperazin-, piperidin- and tetrahydroisoquinolinamides immunoglobulin kappa variable 2D-29 Homo sapiens