Pub. Date : 2008 Jan 15
PMID : 18223231
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These events were likely associated with prevention of HDACI-mediated RelA acetylation and NF-kappaB activation by bortezomib, down-regulation of antiapoptotic proteins (i.e., Bcl-xL, Mcl-1, and XIAP), as well as up-regulation of the proapoptotic protein Bim, resulting in activation of caspase cascade. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | CONCLUSIONS: Coadministration of the clinically relevant HDACIs romidepsin or belinostat with bortezomib synergistically induces cell death in CLL cells, likely through mechanisms involving, among other factors, NF-kappaB inactivation and perturbation in the expression of proapoptotic and antiapoptotic proteins. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |