Title : Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1.

Pub. Date : 2008 Mar

PMID : 18204475






2 Functional Relationships(s)
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1 KEY RESULTS: GSNO stimulated PDE5 phosphorylation and activity and increased cGMP levels in gastric smooth muscle cells. S-Nitrosoglutathione phosphodiesterase 5A Homo sapiens
2 Concurrent activation of cells with ACh augmented GSNO-stimulated PDE5 phosphorylation and activity, and attenuated cGMP levels. S-Nitrosoglutathione phosphodiesterase 5A Homo sapiens