Title : Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1.

Pub. Date : 2008 Mar

PMID : 18204475






3 Functional Relationships(s)
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1 Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. Cyclic GMP ras homolog family member A Homo sapiens
2 Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. Cyclic GMP ras homolog family member A Homo sapiens
3 CONCLUSION AND IMPLICATIONS: In gastrointestinal smooth muscle cGMP levels are cross-regulated by contractile agonists via a mechanism that involves RhoA-dependent, PKC-mediated inhibition of PP1 activity. Cyclic GMP ras homolog family member A Homo sapiens