Pub. Date : 2008 Mar
PMID : 18204475
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. | Cyclic GMP | ras homolog family member A | Homo sapiens |
2 | Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1. | Cyclic GMP | ras homolog family member A | Homo sapiens |
3 | CONCLUSION AND IMPLICATIONS: In gastrointestinal smooth muscle cGMP levels are cross-regulated by contractile agonists via a mechanism that involves RhoA-dependent, PKC-mediated inhibition of PP1 activity. | Cyclic GMP | ras homolog family member A | Homo sapiens |