Pub. Date : 2008 Jan
PMID : 18202014
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report herein the computational identification of a small-molecule inhibitor of PFKFB3, 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), which suppresses glycolytic flux and is cytostatic to neoplastic cells. | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |
| 2 | 3PO inhibits recombinant PFKFB3 activity, suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Homo sapiens |