Title : Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074.

Pub. Date : 2008 May

PMID : 18194435






3 Functional Relationships(s)
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1 Although mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated protein kinase (ERK) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens
2 Although mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated protein kinase (ERK) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens
3 Although mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated protein kinase (ERK) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone mitogen-activated protein kinase kinase 7 Homo sapiens