Pub. Date : 2008 Mar
PMID : 18191995
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin-mediated sensitivity to TRAIL-induced cell death in human granulosa tumor cells. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 2 | Real-time PCR was used for gene expression analysis of the TRAIL receptor dr5 and the pro-apoptotic bax following treatment with cisplatin. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 3 | This effect was enhanced following pre-treatment with cisplatin (25 microM) for 2 or 18 h. Moreover, pre-treatment with cisplatin decreased the maximal effective dose of TRAIL from 100 ng/ml to as low as 3 ng/ml in both cell lines. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 4 | This effect was enhanced following pre-treatment with cisplatin (25 microM) for 2 or 18 h. Moreover, pre-treatment with cisplatin decreased the maximal effective dose of TRAIL from 100 ng/ml to as low as 3 ng/ml in both cell lines. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 5 | While the level of p53 expression enhanced both the death-inducing and TRAIL-sensitizing effects of cisplatin, TRAIL-induced cell death was found to occur independent of p53. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 6 | CONCLUSIONS: These data suggest that the efficacy of cisplatin in GCT cells can be enhanced through combinatorial treatment with TRAIL. | Cisplatin | TNF superfamily member 10 | Homo sapiens |
| 7 | Combinatorial treatment of GCTs with cisplatin and TRAIL may provide an efficacious addition to cisplatin-based regimens. | Cisplatin | TNF superfamily member 10 | Homo sapiens |