PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18191995-0 2008 Cisplatin-mediated sensitivity to TRAIL-induced cell death in human granulosa tumor cells. Cisplatin 0-9 TNF superfamily member 10 Homo sapiens 34-39 18191995-6 2008 Real-time PCR was used for gene expression analysis of the TRAIL receptor dr5 and the pro-apoptotic bax following treatment with cisplatin. Cisplatin 129-138 TNF superfamily member 10 Homo sapiens 59-64 18191995-8 2008 This effect was enhanced following pre-treatment with cisplatin (25 microM) for 2 or 18 h. Moreover, pre-treatment with cisplatin decreased the maximal effective dose of TRAIL from 100 ng/ml to as low as 3 ng/ml in both cell lines. Cisplatin 54-63 TNF superfamily member 10 Homo sapiens 170-175 18191995-8 2008 This effect was enhanced following pre-treatment with cisplatin (25 microM) for 2 or 18 h. Moreover, pre-treatment with cisplatin decreased the maximal effective dose of TRAIL from 100 ng/ml to as low as 3 ng/ml in both cell lines. Cisplatin 120-129 TNF superfamily member 10 Homo sapiens 170-175 18191995-10 2008 While the level of p53 expression enhanced both the death-inducing and TRAIL-sensitizing effects of cisplatin, TRAIL-induced cell death was found to occur independent of p53. Cisplatin 100-109 TNF superfamily member 10 Homo sapiens 71-76 18191995-11 2008 CONCLUSIONS: These data suggest that the efficacy of cisplatin in GCT cells can be enhanced through combinatorial treatment with TRAIL. Cisplatin 53-62 TNF superfamily member 10 Homo sapiens 129-134 18191995-13 2008 Combinatorial treatment of GCTs with cisplatin and TRAIL may provide an efficacious addition to cisplatin-based regimens. Cisplatin 96-105 TNF superfamily member 10 Homo sapiens 51-56