Pub. Date : 2008 May
PMID : 18184928
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: The angiotensin type 1 receptor blocker (ARB) and peroxisome proliferator-activated receptor (PPAR) gamma modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in nondiabetic and diabetic hypertensive patients. | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | OBJECTIVE: The angiotensin type 1 receptor blocker (ARB) and peroxisome proliferator-activated receptor (PPAR) gamma modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in nondiabetic and diabetic hypertensive patients. | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | RESULTS: Telmisartan significantly induced the PPARalpha target genes carnitine palmitoyl transferase 1A (CPT1A) in human HepG2 cells and acyl-CoA synthetase long-chain family member 1 (ACSL1) in murine AML12 cells in the micromolar range. | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |